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  • Links for 2012-03-28 [Digg] March 29, 2012
    Bleeding During Catheterization of Male Urethra I was called at 10.30 PM to attend a case of bleeding from urethra following urethral catheterization in a semiconscious male, admitted to the medicine ward. I went and saw a healthy male in sixties bleeding from urethra. The foley's catheter, a narrow silicon tube used for draining the retained urine was […]
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    A Common Blood Pressure Lowering Drug Verapamil may Slow Or Reverse Diabetes A common medication for high-blood-pressure and angina, verapamil, a calcium channel blocker has been seen to protect or reverse diabetes-related death of pancreatic beta cells, those responsible for secretion of insulin; according to a University of Alabama at Birmingham study publ […]
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DNA Repair in Mice with BRCA1 Gene Mutations

Posted by Dr.Prahallad Panda on April 6, 2010

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It may be possible in the near future that researchers will be able to identify all those factors those play their role in transforming normal cells to abnormal; initiating and sustaining uncontrolled growth, and rendering them resistant to treatment.

clipped from www.cancer.gov Scientists Restore DNA Repair in Mice with BRCA1 Gene Mutations The gene BRCA1 plays an important role in repairing DNA damage that inevitably occurs as cells replicate. Through a pathway known as homologous recombination (HR), the gene helps cells make repairs and prevent further genetic changes that could set the stage for cancer. But as a new study in mice suggests, multiple pathways may actually compete with one another to repair DNA damage within cells. The study further suggests that it may be possible to restore the HR pathway and promote faithful DNA repair in cells with BRCA1 mutations. An enzyme called DNA ligase repairs a broken strand of DNA. (Image courtesy of Dr. Tom Ellenberger, Washington University School of Medicine in St. Louis.) Some repair pathways, he noted, do more harm than good. While the HR pathway is essentially free of errors, the 53BP1-associated pathway produces genetic mutations that increase the risk of cancer when the BRCA1 protein is absent.

This entry was posted on April 6, 2010 at 6:43 pm and is filed under Uncategorized. . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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