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    Bleeding During Catheterization of Male Urethra I was called at 10.30 PM to attend a case of bleeding from urethra following urethral catheterization in a semiconscious male, admitted to the medicine ward. I went and saw a healthy male in sixties bleeding from urethra. The foley's catheter, a narrow silicon tube used for draining the retained urine was […]
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    A Common Blood Pressure Lowering Drug Verapamil may Slow Or Reverse Diabetes A common medication for high-blood-pressure and angina, verapamil, a calcium channel blocker has been seen to protect or reverse diabetes-related death of pancreatic beta cells, those responsible for secretion of insulin; according to a University of Alabama at Birmingham study publ […]
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More Evidence that PPIs Blunt Antiplatelet Activity

Posted by Dr.Prahallad Panda on April 30, 2010

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This link;”http://www.medpagetoday.com/MeetingCoverage/AHA/17058″, is all about the warning of FDA in concomitant use of some proton pump inhibitors (PPI) with clopidogrel; a blood thinning agent usually prescribed after stent placements and other cases of coronary artery disease treatment. It has been seen by the researchers that pantaprazole a PPI prescribed to reduce adverse effect of aspirin, which is also co-prescribed along with clopidogrel may interfere with the action of clopidogrel, adversely affecting the task of blood thinning.

clipped from www.medpagetoday.com The risk of rehospitalization for myocardial infarction (MI) almost doubled in patients treated with both a proton pump inhibitor (PPI) and clopidogrel (Plavix) after acute MI or coronary stent deployment, data from a retrospective cohort study showed. PPIs are frequently used to reduce the risk of gastrointestinal bleeding in patients treated with clopidogrel. However, a growing volume of evidence has suggested that PPIs might reduce clopidogrel’s efficacy, the authors wrote. In one recent study, patients treated with omeprazole (Prilosec) in addition to aspirin and clopidogrel had a significantly higher platelet reactivity index score after seven days of treatment than patients who didn’t get the PPI (J Am Coll Cardiol 2008; 51: 256-60). However, a subgroup analysis of a large clinical trial showed no increased risk of adverse events in patients who received clopidogrel with or without a PPI (Circulation 2008; 118(suppl 2): Abstract 3999).

This entry was posted on April 30, 2010 at 6:59 am and is filed under Uncategorized. . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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