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    A Common Blood Pressure Lowering Drug Verapamil may Slow Or Reverse Diabetes A common medication for high-blood-pressure and angina, verapamil, a calcium channel blocker has been seen to protect or reverse diabetes-related death of pancreatic beta cells, those responsible for secretion of insulin; according to a University of Alabama at Birmingham study publ […]
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Metformin Associated Vitamin B Defficiency

Posted by Dr.Prahallad Panda on May 22, 2010

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The researchers have found out that metformin a medication for obesity and diabetes may cause vitamin B 12 deficiency.

clipped from www.medpagetoday.com Keeping Tabs on Vitamin B Advised with Metformin The association of metformin treatment with vitamin B12 deficiency was confirmed in a long-term trial, suggesting that diabetic patients receiving the popular drug would benefit from vitamin monitoring and perhaps B12 supplementation. With 4.3 years of treatment in a randomized, placebo-controlled trial, the hazard ratio for developing vitamin B12 deficiency while on metformin was 5.5 relative to placebo (95% CI 1.6 to 19.1), reported Coen Stehouwer, MD, of Maastricht University in the Netherlands, and colleagues online in BMJ. “Our study shows that this decrease is not a transitory phenomenon, but persists and grows over time,” the researchers wrote. From a mean of about 355 pmol/L at the end of the run-in phase, B12 levels dropped to about 305 pmol/L after four months, and from there to 280 pmol/L over the next four years.

This entry was posted on May 22, 2010 at 6:41 am and is filed under Uncategorized. . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

2 Responses to “Metformin Associated Vitamin B Defficiency”

1.   Jillian@Moringa Says:
   May 16th, 2011 at 1:49 pm

   Do you know if metformin has any side effects? I’ve become really sceptical over the years – I don’t want to damage my body!

2.   Dr.Prahallad Panda Says:
   May 16th, 2011 at 6:34 pm

   Dear,
   Every drug has some adverse reaction. Metformin is rather a safe drug. One may have GI upset and headache. To minimize it, your doctor will guide you. It is good to start from lower doses and in sustained release form.

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