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    Bleeding During Catheterization of Male Urethra I was called at 10.30 PM to attend a case of bleeding from urethra following urethral catheterization in a semiconscious male, admitted to the medicine ward. I went and saw a healthy male in sixties bleeding from urethra. The foley's catheter, a narrow silicon tube used for draining the retained urine was […]
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    A Common Blood Pressure Lowering Drug Verapamil may Slow Or Reverse Diabetes A common medication for high-blood-pressure and angina, verapamil, a calcium channel blocker has been seen to protect or reverse diabetes-related death of pancreatic beta cells, those responsible for secretion of insulin; according to a University of Alabama at Birmingham study publ […]
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Febuxostat and Allopurinol Combination Works Better in Gout

Posted by Dr.Prahallad Panda on June 21, 2010

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Gout, an arthritic disease having hall mark of affecting the metatarsophalangeal (MTP) joint, the joint of great toe to the foot; is very painful. Colchicine is the specific drug in acurte phase along with a NSAID such as naproxen. In long term allopurinol is used. The target is to get the urate (Uric acid ) level something below 6mg%. Now researcher say combining a newer drug febuxostat may give better result, though disease flares may not reduce.
Another experimental monoclonal antibody, Canakinumab addition may decrease the flares; said the researchers.

clipped from www.medpagetoday.com ROME — Gout patients treated with febuxostat (Uloric) at a dose of 80 mg or 120 mg daily saw greater declines in serum urate levels than those treated with allopurinol 300 mg, researchers said here. At the patients’ final clinic visit, 75% of those treated with febuxostat 80 mg/day achieved urate-lowering to a goal of less than 6 mg/dl, but only 38% of patients taking allopurinol 300 mg/day achieved that goal (P<0.001), according to Michael Becker, MD, of the University of Chicago. When the researchers looked a further urate lowering, they found that 65% of those on the higher febuxostat dose achieved a serum urate level below 5 mg/day, as did 47% on the lower febuxostat dose and just 13% on allopurinol. The differences between both febuxostat treatment groups and the allopurinol group were again significant at P<0.001. Despite lower serum urate levels, no differences were observed between treatments for gout flares or reduction of tophi.

This entry was posted on June 21, 2010 at 9:16 am and is filed under Uncategorized. . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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