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      Bedsores can be Responsible for Considerable Morbidity and Mortality Bedsores can kill almost as many as the hospital superbug MRSA (Methicillin Resistant Staphylococcus Aureus) and cost a lot to the exchequer anywhere in the world. Even when they don’t kill, they inflict terrible pain, discomfort; and rob the sufferer of their time and money. Read more; htt […]
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      Melatonin and Risk of Developing Diabetes Mellitus In addition to inducing sleep, it also acts on different organs of body and influence their functions too. So it regulates the “biological clock” responsible for sleep/wake pattern. It has been seen that people engaged in night shift duty are prone to develop type II diabetes (DM Type II) mellitus, obesity a […]
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Lipid Regulating Gene Number Goes Up

Posted by Dr.Prahallad Panda on August 5, 2010

Control of LDL, the bad cholesterol can now be targeted a a better way; it is hoped.
clipped from www.medpagetoday.com
New Gene Variants Linked to Lipid Levels
In a genetic analysis of more than 100,000 people of European ancestry, researchers have found 95 common genetic variants — 59 of them previously unknown — that influence lipid levels by regulating nearby genes.

And at least one actually causes increases in low-density lipoprotein cholesterol (LDL-C) by decreasing the expression in the liver of a gene called Sort1. The gene lies in a region previously linked to about a 40% increase in the risk of heart attack, but the mechanism has not been understood.

That target may not be the gene product of Sort1 — a protein dubbed sortilin — according to Kathiresan. But the study “exposes basically a new pathway, a new way of regulating lipids, LDL cholesterol, that’s actually independent of or different than previous approaches,” he said.

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