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      Bedsores can be Responsible for Considerable Morbidity and Mortality Bedsores can kill almost as many as the hospital superbug MRSA (Methicillin Resistant Staphylococcus Aureus) and cost a lot to the exchequer anywhere in the world. Even when they don’t kill, they inflict terrible pain, discomfort; and rob the sufferer of their time and money. Read more; htt […]
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      Melatonin and Risk of Developing Diabetes Mellitus In addition to inducing sleep, it also acts on different organs of body and influence their functions too. So it regulates the “biological clock” responsible for sleep/wake pattern. It has been seen that people engaged in night shift duty are prone to develop type II diabetes (DM Type II) mellitus, obesity a […]

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Archive for the 'atherosclerosis' Category

Atherosclerosis: Thickening of Arterial Wall

Posted by Dr.Prahallad Panda on 28th December 2009

Some years back, one of my friends asked me that a person known to him is having pain in the left arm while walking, compelling him to take a break; and gets back the pain sometimes after resuming his walk. I suggested an electrocardiogram (ECG), and as expected by me a coronary artery disease was diagnosed. This symptom is somewhat a tale tell story of angina pain of heart. In my childhood, I have seen dancing of some superficial arteries of old aged persons and surprised over it; now, I am clear about its cause i.e. it is due to thickening of wall of peripheral arteries from atherosclerosis. In atherosclerosis; there occurs deposit of cholesterol, calcium, some blood cells and some other components in the inner layer of blood vessels called intima. This is equally seen larger as well as smaller blood vessels in the body. Smoking is an important cause of atherosclerosis.

Recently, researchers have found out the role of immune cells in the formation of atheroma after triggering an inflammation in the intima of blood vessels. Drugs targeting these cells also cause harm to useful effects of these cells. So, now they are targeting research, how to destroy the bad effect of cells leaving ahead the good effects. They also found out one molecule that switches on the harmful effect of these immune cells. The new research will be focusing more on blocking the action of the molecule.

Pot bellied persons due excess abdominal fat; the apples are prone to develop atherosclerosis than the pears; persons having fat deposit around hip, researchers say. Smoking, alcohol, sedentary life style and more saturated fat consumption are some of the contributing factors for atherosclerosis. Measurements of waist circumference (WC), waist to hip ratio (WHR) and Body mass index (BMI) are some of predictors of risk of heart attack. Waist circumference >32 inches in female and >37 inches in male have the risk of heart attack. Persons having WHR > 0.7 and BMI >30 are at the risk of developing atherosclerosis.

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